diff --git a/Include/internal/pycore_crossinterp.h b/Include/internal/pycore_crossinterp.h
index bed966681fa1f0..da78e0b5b8c79e 100644
--- a/Include/internal/pycore_crossinterp.h
+++ b/Include/internal/pycore_crossinterp.h
@@ -42,6 +42,12 @@ typedef struct _xidata _PyXIData_t;
 typedef PyObject *(*xid_newobjfunc)(_PyXIData_t *);
 typedef void (*xid_freefunc)(void *);
 
+typedef enum {
+    _PyXIData_STATUS_ACTIVE = 0,
+    _PyXIData_STATUS_CLAIMED_BY_SENDER_TEARDOWN,
+    _PyXIData_STATUS_RELEASED,
+} _PyXIData_status_t;
+
 // _PyXIData_t is similar to Py_buffer as an effectively
 // opaque struct that holds data outside the object machinery.  This
 // is necessary to pass safely between interpreters in the same process.
@@ -82,10 +88,14 @@ struct _xidata {
     // to PyMem_RawFree (the default if not explicitly set to NULL).
     // The call will happen with the original interpreter activated.
     xid_freefunc free;
+    int status;   /* one of _PyXIData_status_t */
+    struct _xidata *xid_next;
+    struct _xidata *xid_prev;
 };
 
 PyAPI_FUNC(_PyXIData_t *) _PyXIData_New(void);
 PyAPI_FUNC(void) _PyXIData_Free(_PyXIData_t *data);
+PyAPI_FUNC(void) _PyXIData_CleanupRegistry(PyInterpreterState *interp);
 
 #define _PyXIData_DATA(DATA) ((DATA)->data)
 #define _PyXIData_OBJ(DATA) ((DATA)->obj)
diff --git a/Include/internal/pycore_interp_structs.h b/Include/internal/pycore_interp_structs.h
index d3efac906aeb93..5b419db1747492 100644
--- a/Include/internal/pycore_interp_structs.h
+++ b/Include/internal/pycore_interp_structs.h
@@ -1069,6 +1069,9 @@ struct _is {
     // guards can no longer be created.
     uintptr_t finalization_guards;
 
+    PyMutex xidata_list_mutex;
+    struct _xidata *xidata_list_head;
+
     /* the initial PyInterpreterState.threads.head */
     _PyThreadStateImpl _initial_thread;
     // _initial_thread should be the last field of PyInterpreterState.
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2026-07-15-11-06-00.gh-issue-153713.abcdef.rst b/Misc/NEWS.d/next/Core_and_Builtins/2026-07-15-11-06-00.gh-issue-153713.abcdef.rst
new file mode 100644
index 00000000000000..bdc80a8b501485
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2026-07-15-11-06-00.gh-issue-153713.abcdef.rst
@@ -0,0 +1 @@
+Fix a memory leak in ``_xidata_release`` when the originating interpreter of a ``_PyXIData_t`` object is destroyed before the receiving interpreter releases it. The fix implements a lock-free compare-and-swap mechanism to safely coordinate teardown and release across interpreters.
diff --git a/Python/crossinterp.c b/Python/crossinterp.c
index ed77c1be646e27..4d27d650a54531 100644
--- a/Python/crossinterp.c
+++ b/Python/crossinterp.c
@@ -15,6 +15,62 @@
 #include "pycore_runtime.h"       // _PyRuntime
 #include "pycore_setobject.h"     // _PySet_NextEntry()
 #include "pycore_typeobject.h"    // _PyStaticType_InitBuiltin()
+static void
+_PyXIData_Link(PyInterpreterState *interp, _PyXIData_t *xidata)
+{
+    PyMutex_Lock(&interp->xidata_list_mutex);
+    xidata->xid_next = interp->xidata_list_head;
+    xidata->xid_prev = NULL;
+    if (interp->xidata_list_head != NULL) {
+        interp->xidata_list_head->xid_prev = xidata;
+    }
+    interp->xidata_list_head = xidata;
+    PyMutex_Unlock(&interp->xidata_list_mutex);
+}
+
+static void
+_PyXIData_Unlink(PyInterpreterState *interp, _PyXIData_t *xidata)
+{
+    PyMutex_Lock(&interp->xidata_list_mutex);
+    if (xidata->xid_next != NULL) {
+        xidata->xid_next->xid_prev = xidata->xid_prev;
+    }
+    if (xidata->xid_prev != NULL) {
+        xidata->xid_prev->xid_next = xidata->xid_next;
+    }
+    else if (interp->xidata_list_head == xidata) {
+        interp->xidata_list_head = xidata->xid_next;
+    }
+    xidata->xid_next = NULL;
+    xidata->xid_prev = NULL;
+    PyMutex_Unlock(&interp->xidata_list_mutex);
+}
+
+void
+_PyXIData_CleanupRegistry(PyInterpreterState *interp)
+{
+    PyMutex_Lock(&interp->xidata_list_mutex);
+    _PyXIData_t *head = interp->xidata_list_head;
+    interp->xidata_list_head = NULL;
+    PyMutex_Unlock(&interp->xidata_list_mutex);
+
+    _PyXIData_t *curr = head;
+    while (curr != NULL) {
+        _PyXIData_t *next = curr->xid_next;
+        void *data = curr->data;
+        xid_freefunc free_func = curr->free;
+        PyObject *obj = curr->obj;
+
+        int expected = _PyXIData_STATUS_ACTIVE;
+        if (_Py_atomic_compare_exchange_int(&curr->status, &expected, _PyXIData_STATUS_CLAIMED_BY_SENDER_TEARDOWN)) {
+            if (free_func != NULL) {
+                free_func(data);
+            }
+            Py_XDECREF(obj);
+        }
+        curr = next;
+    }
+}
 
 
 static Py_ssize_t
@@ -373,6 +429,13 @@ _PyXIData_Init(_PyXIData_t *xidata,
         ? PyInterpreterState_GetID(interp)
         : -1;
     xidata->new_object = new_object;
+
+    _Py_atomic_store_int(&xidata->status, _PyXIData_STATUS_ACTIVE);
+    xidata->xid_next = NULL;
+    xidata->xid_prev = NULL;
+    if (interp != NULL) {
+        _PyXIData_Link(interp, xidata);
+    }
 }
 
 int
@@ -1016,6 +1079,10 @@ _PyCode_GetPureScriptXIData(PyThreadState *tstate,
 PyObject *
 _PyXIData_NewObject(_PyXIData_t *xidata)
 {
+    if (_Py_atomic_load_int(&xidata->status) != _PyXIData_STATUS_ACTIVE) {
+        PyErr_SetString(PyExc_RuntimeError, "the originating interpreter has been destroyed");
+        return NULL;
+    }
     return xidata->new_object(xidata);
 }
 
@@ -1040,26 +1107,31 @@ _xidata_release(_PyXIData_t *xidata, int rawfree)
         return 0;
     }
 
-    // Switch to the original interpreter.
-    PyInterpreterState *interp = _PyInterpreterState_LookUpID(
-                                        _PyXIData_INTERPID(xidata));
-    if (interp == NULL) {
-        // The interpreter was already destroyed.
-        // This function shouldn't have been called.
-        // XXX Someone leaked some memory...
-        assert(PyErr_Occurred());
-        if (rawfree) {
-            PyMem_RawFree(xidata);
+    int expected = _PyXIData_STATUS_ACTIVE;
+    if (_Py_atomic_compare_exchange_int(&xidata->status, &expected, _PyXIData_STATUS_RELEASED)) {
+        PyInterpreterState *interp = _PyInterpreterState_LookUpID(_PyXIData_INTERPID(xidata));
+        if (interp != NULL) {
+            _PyXIData_Unlink(interp, xidata);
+            if (rawfree) {
+                return _Py_CallInInterpreterAndRawFree(interp, _call_clear_xidata, xidata);
+            }
+            else {
+                return _Py_CallInInterpreter(interp, _call_clear_xidata, xidata);
+            }
+        }
+        else {
+            if (rawfree) {
+                PyMem_RawFree(xidata);
+            }
+            return -1;
         }
-        return -1;
-    }
-
-    // "Release" the data and/or the object.
-    if (rawfree) {
-        return _Py_CallInInterpreterAndRawFree(interp, _call_clear_xidata, xidata);
     }
     else {
-        return _Py_CallInInterpreter(interp, _call_clear_xidata, xidata);
+        // Already claimed by sender teardown.
+        if (rawfree) {
+            PyMem_RawFree(xidata);
+        }
+        return 0;
     }
 }
 
diff --git a/Python/pystate.c b/Python/pystate.c
index e90642fa882db7..4ecb1b2ae2e94e 100644
--- a/Python/pystate.c
+++ b/Python/pystate.c
@@ -8,6 +8,7 @@
 #include "pycore_ceval.h"         // _PyEval_AcquireLock()
 #include "pycore_codecs.h"        // _PyCodec_Fini()
 #include "pycore_critical_section.h" // _PyCriticalSection_Resume()
+#include "pycore_crossinterp.h"   // _PyXIData_CleanupRegistry()
 #include "pycore_dtoa.h"          // _dtoa_state_INIT()
 #include "pycore_freelist.h"      // _PyObject_ClearFreeLists()
 #include "pycore_initconfig.h"    // _PyStatus_OK()
@@ -598,6 +599,8 @@ init_interpreter(PyInterpreterState *interp,
     interp->executor_ptrs = NULL;
     interp->executor_count = 0;
     interp->executor_capacity = 0;
+    interp->xidata_list_mutex = (PyMutex){0};
+    interp->xidata_list_head = NULL;
     interp->executor_deletion_list_head = NULL;
     interp->executor_creation_counter = JIT_CLEANUP_THRESHOLD;
 
@@ -1030,6 +1033,8 @@ PyInterpreterState_Delete(PyInterpreterState *interp)
 
     zapthreads(interp);
 
+    _PyXIData_CleanupRegistry(interp);
+
     // XXX These two calls should be done at the end of clear_interpreter(),
     // but currently some objects get decref'ed after that.
 #ifdef Py_REF_DEBUG