diff --git a/Lib/ensurepip/__init__.py b/Lib/ensurepip/__init__.py
index 566fb2a096bcfe9..ecfaee5640ea980 100644
--- a/Lib/ensurepip/__init__.py
+++ b/Lib/ensurepip/__init__.py
@@ -116,7 +116,7 @@ def _bootstrap(*, root=None, upgrade=False, user=False,
             additional_paths.append(os.path.join(tmpdir, wheel_name))
 
         # Construct the arguments to be passed to the pip command
-        args = ["install", "--no-index", "--find-links", tmpdir]
+        args = ["install", "--no-cache-dir", "--no-index", "--find-links", tmpdir]
         if root:
             args += ["--root", root]
         if upgrade:
diff --git a/Lib/test/test_ensurepip.py b/Lib/test/test_ensurepip.py
index 89966893092851c..4786d28f39a3d04 100644
--- a/Lib/test/test_ensurepip.py
+++ b/Lib/test/test_ensurepip.py
@@ -40,7 +40,7 @@ def test_basic_bootstrapping(self):
 
         self.run_pip.assert_called_once_with(
             [
-                "install", "--no-index", "--find-links",
+                "install", "--no-cache-dir", "--no-index", "--find-links",
                 unittest.mock.ANY, "setuptools", "pip",
             ],
             unittest.mock.ANY,
@@ -54,7 +54,7 @@ def test_bootstrapping_with_root(self):
 
         self.run_pip.assert_called_once_with(
             [
-                "install", "--no-index", "--find-links",
+                "install", "--no-cache-dir", "--no-index", "--find-links",
                 unittest.mock.ANY, "--root", "/foo/bar/",
                 "setuptools", "pip",
             ],
@@ -66,7 +66,7 @@ def test_bootstrapping_with_user(self):
 
         self.run_pip.assert_called_once_with(
             [
-                "install", "--no-index", "--find-links",
+                "install", "--no-cache-dir", "--no-index", "--find-links",
                 unittest.mock.ANY, "--user", "setuptools", "pip",
             ],
             unittest.mock.ANY,
@@ -77,7 +77,7 @@ def test_bootstrapping_with_upgrade(self):
 
         self.run_pip.assert_called_once_with(
             [
-                "install", "--no-index", "--find-links",
+                "install", "--no-cache-dir", "--no-index", "--find-links",
                 unittest.mock.ANY, "--upgrade", "setuptools", "pip",
             ],
             unittest.mock.ANY,
@@ -88,7 +88,7 @@ def test_bootstrapping_with_verbosity_1(self):
 
         self.run_pip.assert_called_once_with(
             [
-                "install", "--no-index", "--find-links",
+                "install", "--no-cache-dir", "--no-index", "--find-links",
                 unittest.mock.ANY, "-v", "setuptools", "pip",
             ],
             unittest.mock.ANY,
@@ -99,7 +99,7 @@ def test_bootstrapping_with_verbosity_2(self):
 
         self.run_pip.assert_called_once_with(
             [
-                "install", "--no-index", "--find-links",
+                "install", "--no-cache-dir", "--no-index", "--find-links",
                 unittest.mock.ANY, "-vv", "setuptools", "pip",
             ],
             unittest.mock.ANY,
@@ -110,7 +110,7 @@ def test_bootstrapping_with_verbosity_3(self):
 
         self.run_pip.assert_called_once_with(
             [
-                "install", "--no-index", "--find-links",
+                "install", "--no-cache-dir", "--no-index", "--find-links",
                 unittest.mock.ANY, "-vvv", "setuptools", "pip",
             ],
             unittest.mock.ANY,
@@ -260,7 +260,7 @@ def test_basic_bootstrapping(self):
 
         self.run_pip.assert_called_once_with(
             [
-                "install", "--no-index", "--find-links",
+                "install", "--no-cache-dir", "--no-index", "--find-links",
                 unittest.mock.ANY, "setuptools", "pip",
             ],
             unittest.mock.ANY,
diff --git a/Misc/ACKS b/Misc/ACKS
index e85e370c98cc794..8098637a32c5d9d 100644
--- a/Misc/ACKS
+++ b/Misc/ACKS
@@ -885,6 +885,7 @@ Vajrasky Kok
 Guido Kollerie
 Jacek Kołodziej
 Jacek Konieczny
+Krzysztof Konopko
 Arkady Koplyarov
 Peter A. Koren
 Марк Коренберг
diff --git a/Misc/NEWS.d/next/Library/2020-06-15-12-22-53.bpo-40448.1dk8Bu.rst b/Misc/NEWS.d/next/Library/2020-06-15-12-22-53.bpo-40448.1dk8Bu.rst
new file mode 100644
index 000000000000000..a755c5faa671c33
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2020-06-15-12-22-53.bpo-40448.1dk8Bu.rst
@@ -0,0 +1,2 @@
+:mod:`ensurepip` now disables the use of `pip` cache when installing the
+bundled versions of `pip` and `setuptools`.  Patch by Krzysztof Konopko.