diff --git a/.vsts/macos-buildbot.yml b/.vsts/macos-buildbot.yml
index 8a4f6ba8cb8bff1..d9b2297283b0a86 100644
--- a/.vsts/macos-buildbot.yml
+++ b/.vsts/macos-buildbot.yml
@@ -24,7 +24,7 @@ steps:
   clean: true
   fetchDepth: 5
 
-- script: ./configure --with-pydebug --with-openssl=/usr/local/opt/openssl
+- script: ./configure --with-pydebug --with-openssl=/usr/local/opt/openssl --prefix=/opt/python-vsts
   displayName: 'Configure CPython (debug)'
 
 - script: make -s -j4
diff --git a/.vsts/macos-pr.yml b/.vsts/macos-pr.yml
index 8a4f6ba8cb8bff1..d9b2297283b0a86 100644
--- a/.vsts/macos-pr.yml
+++ b/.vsts/macos-pr.yml
@@ -24,7 +24,7 @@ steps:
   clean: true
   fetchDepth: 5
 
-- script: ./configure --with-pydebug --with-openssl=/usr/local/opt/openssl
+- script: ./configure --with-pydebug --with-openssl=/usr/local/opt/openssl --prefix=/opt/python-vsts
   displayName: 'Configure CPython (debug)'
 
 - script: make -s -j4